Oct 23: The Day Elon Changes Everything

Mark your calendar: October 23, 2025. That's the date I believe Elon Musk could finally unveil his Optimus robot - the same project he says will be "the biggest product ever of any kind." If Elon is right, this could be a $30 trillion tipping point...And regular investors have a rare window to move before the switch flips.

Praxis Precision Medicines Stock Doubles - Here's Why

Vandana Singh
October 16, 2025

Praxis Precision Medicines Inc. (NASDAQ:PRAX) stock skyrocketed on Thursday.

  • PRAX is reaching significant price levels. Check the market position here.

The clinical-stage biopharmaceutical company released topline results for the Phase 3 Essential3 program of ulixacaltamide in essential tremor (ET).

Essential tremor is a neurological disorder that causes involuntary, rhythmic shaking, most commonly in the hands and arms during movement, but it can also affect the head, voice, or legs.

Also Read: Praxis’ Epilepsy Treatment Shows Promise With Decreased Seizures

Study 1: Placebo-controlled Parallel Group Study Topline Efficacy Results

Study 1 showed a statistically significant and clinically meaningful 4.3 point mean improvement in the mADL11 score at Week 8 (p<0.0001).

The effect was sustained from Week 2 throughout the 12-week dosing period. All key secondary endpoints achieved statistical significance.

mADL11 is a modified score that is calculated as the sum of all 11 items and ranges from 0 to 33, where larger values represent increased direct tremor impact on activities of daily living.

Study 2: Randomized Withdrawal Study Topline Efficacy Results

In Study 2, after blinded exposure for 8 weeks with ulixacaltamide, patients meeting the responder criteria (n=80) were randomized to continue receiving ulixacaltamide or switch to placebo for an additional 4 weeks.

55% of patients in the ulixacaltamide arm maintained response vs 33% in the placebo group (p=0.0369).

The first key secondary endpoint – rate of disease improvement – achieved statistical significance, and other secondary endpoints (the Patient Global Impression of change, PGI-C), and Clinical Global Impression of severity, CGI-S) were numerically in favor of ulixacaltamide, but not statistically significant.

Combined Study 1 and Study 2 Hypotheses

Hypothesis 3 and 4 further supported the precision of the effect of ulixacaltamide versus placebo.

  • For Hypothesis 3, there was a 4.3 point improvement in mADL11 at Week 8 for the combined Studies 1 and 2 ulixacaltamide groups vs Study 1 placebo (p<0.0001).
  • For Hypothesis 4, there was a 4.2 point improvement in mADL11 at Week 8 for the Study 2 ulixacaltamide group vs the Study 1 placebo (p<0.0001), respectively.

Ulixacaltamide was generally well tolerated over 12 weeks of treatment. The most common (≥10% patients) treatment-emergent adverse events (TEAs) were constipation, dizziness, euphoric mood, brain fog, headache, paraesthesia, and insomnia. There were no deaths and no drug-related serious adverse events.

Discontinuations were primarily due to TEAEs, with the most common being dizziness and brain fog.

Praxis has submitted a pre-NDA meeting request to the FDA with plans to submit the NDA by early 2026.

PRAX Price Action: Praxis Precision Medicine shares were up 123.19% at $128 during premarket trading on Thursday. The stock is trading at a new 52-week high, according to Benzinga Pro data.

Read Next:

  • IBM Rolls Out Three New AI Agents On Oracle Platform

Photo via Shutterstock

Continue Reading...

Popular

Dutch Supreme Court rejects Russia's final appeal in $50B Yukos case

THE HAGUE, Netherlands (AP) — The Dutch Supreme Court on Friday rejected a final appeal by against a $50 billion arbitration award to former shareholders of Russian oil giant Yukos, who claimed Moscow deliberately bankrupted the company more than 20 years ago.

Elon's Secret Project Could Change Everything... - Ad

Inside Elon Musk's Memphis site lies a supercomputer built to power the world's first superhuman AI. It could make Elon a trillionaire - and new millionaires, too. With just $500, you could get in before the November 1st funding window closes.

The government shutdown is putting a renewed spotlight on the cracks in the US aviation system

A startling message came over the radio from an air traffic control tower near Los Angeles less than a week into the federal government shutdown: “The tower is closed due to staffing."

Magnolia Oil & Gas Gets Upgrade On Strong Finances, Brighter Oil Outlook

KeyBanc raised Magnolia Oil & Gas to Overweight with a $29 target, citing a defensive profile and disciplined growth outlook.

Here's Your Rare "Second Chance" Starting October 23rd - Ad

Missed Bitcoin, Nvidia, or Tesla? Jeff Brown - the tech insider who called them early - says your second chance is here. On October 23rd, a new AI breakthrough could launch a market 14X bigger than the ChatGPT boom. And you can get in for as little as $50.

Bitcoin Steadies Above $110,000 As Ethereum, XRP, Dogecoin Slip On Thursday

Bitcoin is holding steady around $110,000 despite $94 million in net outflows from spot BTC ETFs on Wednesday.

Elon's New Device Could Launch Biggest IPO of the Decade - Ad

Elon Musk's new device is being called a "game-changer"-and even the White House is using this tech. Jeff Brown says it could launch Musk's next trillion-dollar company and make early investors rich. You can claim a stake now for as little as $500.

USA Rare Earth (USAR) Stock Is Rising Today: Here's Why

Shares of USA Rare Earth, Inc. (NASDAQ: USAR) are trading higher Monday amid a wave of optimism for rare earth materials companies.

Microsoft: Russia, China increasingly using AI to escalate cyberattacks on the US

WASHINGTON (AP) — Russia, China, Iran and North Korea have sharply increased their use of artificial intelligence to deceive people online and mount cyberattacks against the United States, according to new research from Microsoft.

On October 16, a powerful new law signed by President Trump will trigger a radical shift in America's money system... - Ad

When a small group of private companies - not the Fed - will perform a major mint of a new kind of money. And those who act before this new system fully kicks in could see gains as high as 40X by 2032. But those who fail to prepare will be blindsided by this sea change to the U.S. dollar.

Why Is BTQ Technologies Stock Up Today?

Shares of BTQ Technologies Corp. (NASDAQ:BTQ) are rising Thursday after the company announced that it reached a significant technological milestone.

This CEO Once Said 'No' To Peter Thiel — Years Later, He Had A Face-Palm Moment When That 'Mistake' Cost Him $200 Million In Palantir Equity

Y Combinator CEO Garry Tan revealed that declining Peter Thiel's early offer to join Palantir Technologies cost him an estimated $200 million in equity — a decision he now calls his most painful career lesson as Palantir's value has soared past $425 billion.

Trump's Radical Plans for the Dollar - Ad

The Fed just slashed rates... yet mortgages have already soared higher. Meanwhile, Trump has his own plan for the dollar - a radical upgrade to our currency, already moving more money than Visa and Mastercard combined. Tech investor Eric Wade calls it the "Smart Dollar."

Trump approves Alaska mining road to boost copper, zinc production

WASHINGTON (AP) — President Donald Trump on Monday ordered approval of a proposed 211-mile road through an Alaska wilderness to allow mining of copper, cobalt, gold and other minerals.

California to begin selling affordable, state-branded insulin beginning next year

LOS ANGELES (AP) — Gov. Gavin Newsom said Thursday that California will begin selling affordable insulin under its own label on Jan. 1, after a partnership to sell state-branded generic drugs at lower prices.

Elon's $25 Trillion Confession - Ad

Elon Musk: "Tesla will become a $25 trillion company." That would make Tesla 8x bigger than Apple today. How is that possible? He admits it's all thanks to this one AI breakthrough that will take AI out of our computer screens and manifest a 250x boom here in the real world.

News organizations, including Hegseth's former employer Fox, reject new Pentagon reporting rules

Fox News, the former employer of Defense Secretary Pete Hegseth, has joined a near-unanimous outpouring of news organizations rejecting new rules for journalists based in the Pentagon.

Judge temporarily blocks the Trump administration from firing workers during the government shutdown

SAN FRANCISCO (AP) — President Donald Trump’s administration for now must stop firing workers during , a federal judge ordered on Wednesday.

November 18: D-Day For The Dollar - Ad

A quiet shift in U.S. law has just authorized private companies to mint a new form of government-authorized money called the "Dollar 2.0"... and the next major mint hits on November 18. Investors who make the right moves before then could make up to 40X by 2032...

Apple iPhone 17 Pro, Pro Max Ship Times Stay Stable Globally: Analyst

Apple's iPhone 17 Pro and Pro Max maintain stable lead times globally, while the iPhone Air is widely available. Analyst maintains Buy rating with $270 price target.

ChatGPT Says Solana's $240 Test Could Decide Its Entire Bull Run

Solana (CRYPTO: SOL) is up over 2% on Monday, with an AI-based forecast highlighting a decisive breakout test around the $240 resistance zone.

Elon Musk Recently Bought $1 Billion Worth of Tesla Shares. - Ad

That's his biggest personal buy in 5 years. My research suggests he's doing it ahead of Tesla's launch of the Optimus robot... An AI-powered robot that Elon himself calls "the biggest product ever of any kind." But here's the thing: Tesla is already a trillion-dollar company. Unless you've got $1 billion like Elon, buying Tesla stock is probably not the best way to play the Optimus launch. That's why I've uncovered a "backdoor" Optimus play most Americans don't know about...

Journalists turn in access badges, exit Pentagon rather than agree to new reporting rules

WASHINGTON (AP) — Dozens of reporters turned in access badges and exited the Pentagon on Wednesday rather than agree to government-imposed , pushing journalists who cover the American military further from the seat of its power. The U.S. government has called the new rules “common sense.”

Silver Nears $50 Amid Inventory Crisis, Outpacing Gold

Silver prices closed last week at multi-year highs, coming within reach of their 2011 peak of $49.95 per ounce.

The Tesla Shock Nobody Sees Coming - Ad

While headlines scream "Tesla is doomed"...Jeff Brown has uncovered a revolutionary AI breakthrough buried inside Tesla's labs. One that is helping AI escape from our computer screens and manifest itself here in the real world all while creating a 25,000% growth market explosion starting as early as October 23rd.

Ethereum Crashes To $4,100 As Senate Democrats Take Aim At DeFi

Ethereum (CRYPTO: ETH) is trading near $4,100 on Friday, after a sharp selloff that followed its rejection from $4,700 and renewed fears of U.S.

Oct 23: The Day Elon Changes Everything - Ad

Mark your calendar: October 23, 2025. That's the date I believe Elon Musk could finally unveil his Optimus robot - the same project he says will be "the biggest product ever of any kind." If Elon is right, this could be a $30 trillion tipping point...And regular investors have a rare window to move before the switch flips.

Senate confirmation of Trump nominee cements his shake-up of top civil rights agency

The Senate confirmed President Donald Trump's pick to fill a critical vacancy at the top agency for worker rights, restoring it to the full power needed to deepen his overhaul of civil rights enforcement.

Elon's Secret Project Could Change Everything... - Ad

Inside Elon Musk's Memphis site lies a supercomputer built to power the world's first superhuman AI. It could make Elon a trillionaire - and new millionaires, too. With just $500, you could get in before the November 1st funding window closes.

A hungrier, poorer and more anxious Iran awaits 'snapback' of UN sanctions over its nuclear program

DUBAI, United Arab Emirates (AP) — As Iran's ailing economy braced Saturday for over its nuclear program, it is ordinary people who increasingly find themselves priced out of the food they need to survive and worried about their futures.

EPAM Joins Oracle To Boost AI And Cloud For Businesses

EPAM deepens partnership with Oracle to help companies in various sectors adopt OCI and AI services, leveraging their expertise.

Here's Your Rare "Second Chance" Starting October 23rd - Ad

Missed Bitcoin, Nvidia, or Tesla? Jeff Brown - the tech insider who called them early - says your second chance is here. On October 23rd, a new AI breakthrough could launch a market 14X bigger than the ChatGPT boom. And you can get in for as little as $50.

Nvidia's Value Reaches $4.6 Trillion, Bitcoin Eyes $120,000: What's Moving Markets Thursday?

On the second day of the U.S. government shutdown, Wall Street remains largely subdued, with indexes showing only slight midday declines after touching fresh record highs at the open.

Elon's New Device Could Launch Biggest IPO of the Decade - Ad

Elon Musk's new device is being called a "game-changer"-and even the White House is using this tech. Jeff Brown says it could launch Musk's next trillion-dollar company and make early investors rich. You can claim a stake now for as little as $500.

Here's How Much $100 Invested In CrowdStrike Holdings 5 Years Ago Would Be Worth Today

CrowdStrike Holdings (NASDAQ: CRWD) has outperformed the market over the past 5 years by 13.93% on an annualized basis producing an average annual return of 28.7%. Currently, CrowdStrike Holdings has a market capitalization of $120.96 billion.

Trending Now

Information, charts or examples are for illustration and educational purposes only and not for individualized investment management This message contains commercial elements, such as advertising. We only send these offers to those who have opted in to our newsletter. Past performance is not indicative of future results. For these reasons we strongly suggest trading in a DEMO/Simulated account. The information provided by us is for educational and informational purposes only. We make no representations or warranties concerning the products, practices or procedures of any company or entity mentioned or recommended and have not determined if the statements and opinions of the advertiser are accurate, correct or truthful. If you use, act upon or make decisions in reliance on information contained or any external source linked within it, you do so at your own peril and agree to hold us, our officers, directors, shareholders, affiliates and agents without fault.

Copyright traderelite.club
Privacy Policy | Terms of Service